- A Case of Hepatocellular Carcinoma Presenting as a Solitary Bone Metastasis of Humerus
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Yun-Ji Park, Pyeong-Suk Yim, In-Hee Kim, Dae-Ghon Kim
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Journal of the Korean Liver Cancer Study Group. 2010;10(1):76-81. Published online June 30, 2010
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Abstract
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- Extrahepatic spread of hepatocellular carcinoma is uncommon. Also, initial clinical presentation that manifests as
symptomatic metastasis is unusual. We experienced a case the bone tumor originated from hepatocellular carcinoma that was
diagnosed and successfully treated in spite of lack of histological findings. A 76-year-old man presenting severe pain of left
upper arm, came to our department of orthopedic surgery and was referred to our hepatology due to be presumed left arm
bone tumor as the metastatic hepatocellular carcinoma. Magnetic resonance image and positron emission tomography revealed
multinodular hepatocellular carcinoma and single metastatic tumor of left upper arm. A part of left upper arm suggested to
metastatic bone tumor was removed by surgical resection and replaced to artificial bone cement. The final pathological result
the bone tumor tissue obtained by surgical resection was assumed an extrahepatic metastasis from unknown origin carcinoma.
It was difficult to prove whether the humerus metastatic bone tumor was originated from primary hepatocellular carcinoma
obviously, in view of pathologic findings. However, we could not find out any other primary carcinoma except hepatocellular
carcinoma, unavoidably diagnosed humerus metastatic tumor as extrahepatic bone metastasis originating from primary
hepatocellular carcinoma.
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